Embargoed and Restricted Access
Reason: Under embargo until May 2022. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library
An investigation into the function of KATNAL2 in male fertility and health
thesis
posted on 2018-05-02, 02:42 authored by JESSICA ELIZABETH MAREE DUNLEAVYMale infertility affects one in twenty men of reproductive age in Australia. Despite this the underlying causes of many common defects remain poorly defined. This thesis predominantly explored the processes by which spermatogonial stem cells transform into aerodynamic, motile sperm capable of fertilising an egg. Using sophisticated experimental approaches, previously overlooked mechanisms were identified to be of critical relevance to male fertility and to cell biology more broadly. The discoveries made in this project will aid in understanding the causes of genetic based infertility, and, in addition, have provided insight into the pathophysiology of other diseases including hydrocephaly.