File(s) under permanent embargo

Reason: Under embargo until August 2021. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library or by emailing document.delivery@monash.edu

An analysis of strain diversity in Clostridium difficile and development of a targeted immunotherapeutic

thesis
posted on 18.08.2018, 08:03 by BLISS ALICE CUNNINGHAM
Clostridium difficile is recognised as the leading cause of bacterial antibiotic-associated diarrhoea worldwide. While these antibiotics successfully treat disease patients remain susceptible to recurrent infection by preventing reestablishment of the protective bacteria in the gut, therefore non-antibiotic alternatives are required. This thesis explored the use of targeted bovine colostrum to prevent disease. By targeting multiple aspects of the C. difficile life cycle, we were able to successfully prevent fulminant disease in mice. We also demonstrated the importance of considering the many different types of C. difficile strains when designing a treatment, to ensure optimal efficacy.

History

Principal supervisor

Dena Lyras

Additional supervisor 1

Melanie Hutton

Year of Award

2018

Department, School or Centre

Microbiology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences

Exports

Exports