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Reason: Under embargo until August 2021. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library
An analysis of strain diversity in Clostridium difficile and development of a targeted immunotherapeutic
thesis
posted on 2018-08-18, 08:03 authored by BLISS ALICE CUNNINGHAMClostridium difficile is recognised as the leading cause of bacterial antibiotic-associated diarrhoea worldwide. While these antibiotics successfully treat disease patients remain susceptible to recurrent infection by preventing reestablishment of the protective bacteria in the gut, therefore non-antibiotic alternatives are required. This thesis explored the use of targeted bovine colostrum to prevent disease. By targeting multiple aspects of the C. difficile life cycle, we were able to successfully prevent fulminant disease in mice. We also demonstrated the importance of considering the many different types of C. difficile strains when designing a treatment, to ensure optimal efficacy.