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An Integrated Systems Biology Approach to the Discovery and Characterisation of Novel Regulators of Hepatic Lipid Metabolism

posted on 30.10.2020, 00:38 by MICHAEL FITZGERALD KEATING
The epidemic of obesity worldwide has contributed to the meteoric rise in the chronic metabolic disorders such as fatty liver disease and cardiovascular disease. Underlying these chronic conditions is a disruption to the metabolism of fat, which predominately occurs in the liver. Given this, the research focus of this thesis was to identify new proteins and pathways that have the potential to be targeted by drug therapy, or act as biomarkers of metabolic disease, through a cutting-edge discovery platform.


Principal supervisor

Anna Calkin

Year of Award


Department, School or Centre

Central Clinical School

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences