Adenosine A2B Receptor Pharmacology and its Role in Pathophysiology
thesisposted on 14.08.2017 by ELIZABETH ANN VECCHIO
In order to distinguish essays and pre-prints from academic theses, we have a separate category. These are often much longer text based documents than a paper.
The adenosine A2B receptor is an important but poorly understood drug target. This thesis investigated new paradigms of adenosine A2B receptor signalling and behaviour and identified drugs that could selectively promote beneficial outcomes in prostate cancer cells and cardiac fibroblasts. This information helps to inform how targeting the adenosine A2B receptor may be used as a treatment for prostate cancer and cardiovascular disease.