Adenosine A2B Receptor Pharmacology and its Role in Pathophysiology

The adenosine A_2B receptor is an important but poorly understood drug target. This thesis investigated new paradigms of adenosine A_2B receptor signalling and behaviour and identified drugs that could selectively promote beneficial outcomes in prostate cancer cells and cardiac fibroblasts. This information helps to inform how targeting the adenosine A_2B receptor may be used as a treatment for prostate cancer and cardiovascular disease.