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Addressing current limitations in the synthesis of dicarba peptides
thesisposted on 20.02.2018, 01:35 by ELLEN CHRISTINA GLEESON
The broad range of biological activity and exquisite selectivity of peptides and proteins have lead to rapidly increasing interest of these molecules as drug candidates. Although previously limited by their poor pharmacokinetic profiles, design and synthesis of peptidomimetics with enhanced therapeutic potential has lead to a renaissance in this area. One such modification, which is explored in this thesis, is the installation of carbon-carbon bridges into peptides via ring-closing metathesis. This thesis aims to address current limitations in the synthesis of dicarba peptides.