File(s) under permanent embargo

Reason: Under embargo until February 2019. After this date a copy can be supplied under Section 51 (2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library or by emailing document.delivery@monash.edu

Addressing current limitations in the synthesis of dicarba peptides

thesis
posted on 20.02.2018, 01:35 by ELLEN CHRISTINA GLEESON
The broad range of biological activity and exquisite selectivity of peptides and proteins have lead to rapidly increasing interest of these molecules as drug candidates. Although previously limited by their poor pharmacokinetic profiles, design and synthesis of peptidomimetics with enhanced therapeutic potential has lead to a renaissance in this area. One such modification, which is explored in this thesis, is the installation of carbon-carbon bridges into peptides via ring-closing metathesis. This thesis aims to address current limitations in the synthesis of dicarba peptides.

History

Campus location

Australia

Principal supervisor

Andrea Robinson

Year of Award

2018

Department, School or Centre

Chemistry

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Science

Usage metrics

Exports