Monash University

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Reason: Under embargo until July 2020. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

A systems biology approach indicates novel triazine compounds may impact a nuclear mechanism in Plasmodium falciparum

posted on 2019-07-23, 07:02 authored by KATHERINE MAY ELLIS
Malaria is a severe parasitic disease which claims over 400,000 lives annually. Drug resistance to the first line antimalarials is spreading and new medicines are desperately required. The research detailed in this thesis provides new information about the mechanism of action of the novel triazine antimalarials. It demonstrates the potent and rapid action of the compounds across the blood stages of the parasite life-cycle, and indicates a novel, nuclear related mechanism of action. This new mechanistic understanding will underpin the ongoing drug discovery efforts based on this novel class of antimalarial compounds.


Principal supervisor

Darren John Creek

Year of Award


Department, School or Centre

Drug Delivery, Disposition and Dynamics


Doctor of Philosophy

Degree Type



Faculty of Pharmacy and Pharmaceutical Sciences