A systems biology approach indicates novel triazine compounds may impact a nuclear mechanism in Plasmodium falciparum

Malaria is a severe parasitic disease which claims over 400,000 lives annually. Drug resistance to the first line antimalarials is spreading and new medicines are desperately required. The research detailed in this thesis provides new information about the mechanism of action of the novel triazine antimalarials. It demonstrates the potent and rapid action of the compounds across the blood stages of the parasite life-cycle, and indicates a novel, nuclear related mechanism of action. This new mechanistic understanding will underpin the ongoing drug discovery efforts based on this novel class of antimalarial compounds.