A study of human interferon-induced IFI60 protein and STAT1 gene regulation

In cells exposed to interferons (IFNs), a large number of specific cellular genes, known as IFN stimulated genes (ISGs), are transcriptionally activated to elicit the myriad of biological responses to IFNs, including antiviral, antiproliferative, differentiative and immunomodulatory effects. This study was undertaken to better understand the roles played by one such ISG, IFI60, in mediating the actions of IFN in cells. […]