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A stereoselective isoprenoid synthetic methodology and the preparation of a mycobacterial antigen

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thesis
posted on 28.02.2017 by Cao, Jia
This thesis describes two separate research projects. The first one focused on the development of a new asymmetric synthetic methodology to construct isoprenoid moieties, which are present in a range of important bioactive natural products. Then the developed methodology was applied to the synthesis of several selected natural products, including a sex pheromone, fragrances, the side chain of zaragozic acid C, an intermediate of tuberculostearic acid, and the side chain of vitamin E. A purported natural product, with antibacterial and antifungal activities, (R)-2-methylheptyl isonicotinate, was also prepared. The second project focused on the preparation of a mycobacterial antigen, BbGLIIc, for evaluation of its immunological response.

History

Campus location

Australia

Principal supervisor

Patrick Perlmutter

Year of Award

2013

Department, School or Centre

Chemistry

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Science

Exports