A novel stress-induced protein disaggregase assembly pathway in primates

Keeping the right amount and working order of cellular proteins is crucial. The breakdown of this balance is a key factor in ageing and diseases. Protein clumping, a major contributor, triggers cell damage. In multicellular organisms, Hsp70 proteins help clear these clumps. We wanted to know how this process is regulated during stress recovery in primate cells. We discovered a special pathway called siDAP that evolved in primates. When activated, siDAP helps primate cells quickly dissolve harmful clumps caused by stress, aiding cell repair. This finding sheds light on treating proteostasis-related diseases and ageing.