Constance Gaya Cremers Final Masters Thesis.pdf (8.53 MB)
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A network-level investigation of signalling crosstalk and drug response in aggressive breast cancer

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posted on 2019-11-08, 04:13 authored by CONSTANCE GAYA CREMERS
This thesis is focused on examining drug resistance mechanisms in an aggressive form of breast cancer. In particular, this work investigates how loss of the tumour suppressor gene PTEN, a common genetic disruption in breast cancer, influences the response to anti-cancer therapies. To achieve this, experimental investigations were combined with mathematical modelling. Research into this area is important as drug resistance is a major challenge and unmet medical need in many cancers, including breast cancer.


Principal supervisor

Lan Nguyen

Additional supervisor 1

Roger Daly

Year of Award


Department, School or Centre

Biochemistry and Molecular Biology

Campus location



Master of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences