A network-level investigation of signalling crosstalk and drug response in aggressive breast cancer

This thesis is focused on examining drug resistance mechanisms in an aggressive form of breast cancer. In particular, this work investigates how loss of the tumour suppressor gene PTEN, a common genetic disruption in breast cancer, influences the response to anti-cancer therapies. To achieve this, experimental investigations were combined with mathematical modelling. Research into this area is important as drug resistance is a major challenge and unmet medical need in many cancers, including breast cancer.