Monash University
Thesis final ammendments.pdf (14.92 MB)

A functional exploration as to how antibiotic resistance mutations occurring in daptomycin resistant isolates of Staphylococcus aureus impede dendritic cell activation

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posted on 2020-03-24, 05:10 authored by TIMOTHY PHILLIP PATTON
Staphylococcus aureus, colloquially referred to as ‘golden staph’, represents an emerging threat to public health, with broadly antibiotic resistant strains circulating in the hospital setting. Findings of this thesis have shown that changes occurring within the bacteria during antibiotic therapy, to help the bacteria evade those antibiotics, have further consequences impeding the ability of dendritic cells, a type of innate sensor cells, to detect these bacteria; therefore impeding immune clearance of these bacteria. In explaining how these bacteria avoid immune destruction, this thesis provides a framework for future research into potential immune based non-antibiotic therapies to cure these infections.


Principal supervisor

Meredith O'Keeffe

Additional supervisor 1

Anton Y. Peleg

Additional supervisor 2

Kristin Radford

Additional supervisor 3

Rosemary Ffrench

Year of Award


Department, School or Centre

Biomedical Sciences (Monash Biomedicine Discovery Institute)

Additional Institution or Organisation

Biochemistry and Molecular Biology

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences