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A Systems Characterisation of Protein Signalling Networks, Cellular Heterogeneity, and Adaptive Drug Resistance

thesis
posted on 2023-11-05, 12:13 authored by ANTHONY JAMES HART
There are many differences between cancer patients that cause some to respond well to drug treatments and some to respond poorly. This thesis explored how the differences between patients translate to changes in the complex cellular networks that are targeted by cancer drugs, and how these changes might be associated with drug resistance. We then attempted to generate computational models of specific cell types to see if we could identify cell-type specific drug combinations to effectively inhibit cancerous proliferation and overcome drug resistance.

History

Principal supervisor

Lan Nguyen

Additional supervisor 1

Sungyoung Shin

Year of Award

2023

Department, School or Centre

Biomedical Sciences (Monash Biomedicine Discovery Institute)

Additional Institution or Organisation

Biochemistry and Molecular Biology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences