A Structural Characterisation and Application of Monoclonal scFvs against Annexin A2 and S100A10

McInerney, Kapil Mathew

doi:10.26180/29652713.v1

A Structural Characterisation and Application of Monoclonal scFvs against Annexin A2 and S100A10

https://doi.org/10.26180/29652713

thesis

posted on 2025-07-28, 01:42 authored by Kapil Mathew McInerney

AIIt is a protein complex that has been found to be associated with cancer cell metastasis - the process by which cancer cells migrate from their original site of development. While targeting AIIt for treatment could potentially be useful, there is no means to specifically detect AIIt in patients. The study explored using small antibody fragments called scFvs as a possible solution. It was found that these scFvs enabled specific detection of AIIt in both plasma and tissue samples, invaluably aiding in the diagnostic process and facilitating treatment.<p></p>

History

Principal supervisor

Hong Ping Ruby Law

Additional supervisor 1

James Whisstock

Additional supervisor 2

Tom Caradoc-Davies

Year of Award

2025

Department, School or Centre

Biochemistry and Molecular Biology

Additional Institution or Organisation

Biomedicine Discovery Institute (BDI)

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences

Rights Statement

The author retains copyright of this thesis. It must only be used for personal non-commercial research, education and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission. For further terms use the In Copyright link under the License field.