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A Metabolic Glycan Labelling Based Approach for Highly Selective Gastrointestinal Delivery

thesis
posted on 2024-06-06, 06:00 authored by Yuen LamYuen Lam

Metabolic glycan labelling utilises unnatural sugar analogues to decorate cell surfaces with specific functional groups, enabling specific delivery of probes through bioorthogonal targeting, a Nobel Prize-winning approach. While this approach has been used for tumours, its potential in intestinal tissues via oral administration is unexplored. This study employed DBCO-sugar to modify intestinal surfaces, facilitating the attachment of 'clickable' particles to potentially extend their residence in the gut. Successful labelling of mucus in cells and tissues was demonstrated, highlighting promising avenues for the use of metabolic glycan labelling in targeted intestinal drug delivery.

History

Campus location

Australia

Principal supervisor

Ben Boyd

Additional supervisor 1

Kristian Kempe

Additional supervisor 2

Angel Tan

Year of Award

2024

Department, School or Centre

Drug Delivery, Disposition and Dynamics

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Pharmacy and Pharmaceutical Sciences

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