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A Checkpoint that Links mRNA Export Competence with Replication Stress and Genomic Integrity

posted on 29.07.2021, 00:52 by TOBIAS DANA WILLIAMS
Cancer has classically been regarded as a disease of gene expression, whereby information from DNA, namely RNA, is used to synthesise a functional gene product such as protein. Recent evidence has highlighted that proteins involved in transport of RNA are systematically altered in a variety of cancers but the picture is far from complete. I have discovered a completely new RNA checkpoint that regulates the transport of damaged RNA. Characterisation of this novel pathway will provide new information on how cells respond to stress and how this contributes to the development and progression of cancer.


Principal supervisor

Richard Pearson

Additional supervisor 1

Vihandha Wickramasinghe

Year of Award


Department, School or Centre

Biochemistry and Molecular Biology

Additional Institution or Organisation

Peter MacCallum Cancer Centre

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences

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