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4-Acryloylmorpholine-Based Bottle Brush Polymers as Drug Carrier Candidate: Synthesis and Evaluation of Their Performance in Biological System

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posted on 12.07.2021, 07:41 authored by ERNY SAGITA
Many efforts have been made to improve current disease treatment, one of which uses a nano-carrier to help deliver an already-established drug. This thesis aimed to develop a platform of cylindrical shape polymeric nano-carrier using a simple and straightforward method of synthesis and purification. The produced polymeric nano-carriers demonstrated excellent physicochemical characteristics for use in biomedical application. In the pre-clinical studies in rodents they showed extended blood circulation, low accumulation in healthy organs and high disposition in tumour tissue. These promising results suggest the potency of our bottle-brush polymer as a new drug delivery carrier candidate for clinical application.


Campus location


Principal supervisor

Joaquin Sanchis Martinez

Additional supervisor 1

Sebastien Perrier

Year of Award


Department, School or Centre

Drug Delivery, Disposition and Dynamics


Doctor of Philosophy

Degree Type



Faculty of Pharmacy and Pharmaceutical Sciences