This technical report summarises the progress and findings of cytotoxicity and cyanotoxins profiling of Tasik Taman Aman, one of the work packages in PJ SEED 5.0 “Guarding Our Water Together: Unveiling the Hidden World of Water Security and Ecosystems”. The report covers the background of the study, the project design and the findings obtained. Recommendations and future perspectives are also included in this report.