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Improving the efficacy of CAR T cell therapies for solid tumours

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posted on 2024-06-28, 05:15 authored by Weronika Kulakowska

CAR T cell therapy has shown great promise in a variety of blood cancers; however, is still yet to prove effective in solid tumours. Solid tumours are often characterised by immunosuppressive microenvironment, which decreases the efficacy of immunotherapies. This project aims to overcome this issue by pre-treating solid tumours with a drug, which can prime the immunosuppressive microenvironment and increase the efficacy of CAR T cell treatments.


The methods include production of CAR T cells targeting antigens commonly expressed on solid tumours, and investigating their effect in combination with different established chemotherapeutic agents.

History

Year

2024

Institution

Monash University

Faculty

Faculty of Medicine, Nursing and Health Sciences

Student type

  • PhD

ORCID

https://orcid.org/0009-0005-9533-4082

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