File(s) stored somewhere else
Please note: Linked content is NOT stored on Monash University and we can't guarantee its availability, quality, security or accept any liability.
Role of phosphoinositide 3-kinases in regulating cardiac function
journal contributionposted on 03.11.2016 by Lynette Pretorius, Kate Owen, Julie McMullen
Any type of content formally published in an academic journal, usually following a peer-review process.
Phosphoinositide 3-kinases (PI3Ks) are important signaling proteins in the heart. Class IA PI3Ks (p110alpha, beta) are critical regulators of physiological heart growth and cell survival, and are generally considered to be beneficial for heart function. In contrast, activation of class IB PI3K(p110gamma) is detrimental for heart function, reducing cardiac contractility. This may have implications for the treatment of heart disease and failure. In vitro, ex vivo and in vivo studies have contributed to our understanding of PI3K signaling in the heart. This review summarizes class I PI3K signaling in the regulation of cardiac function, with a particular focus on the role of different PI3K isoforms in settings of heart disease.