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Wolbachia-mediated blocking of dengue virus in mosquito cells is due in part to the action of the RNAi pathway

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posted on 2018-03-21, 15:08 authored by gerard.terradas@monash.edu, albert.joubert@monash.edu, Elizabeth McGrawElizabeth McGraw
The first dataset examines the effect of Wolbachia infection on genes representing the major innate immune pathways in Aedes aegypti cells. 

The second data set  reports the effects of siRNA designed to target these genes on their expression and on dengue virus loads in Wolbachia infected and Wolbachia free cells. 

The last dataset reports the effects of treatment with combinations of siRNAs targeting multiple immune pathways on the genes expression and dengue virus loads in Wolbachia infected and Wolbachia free cells. 

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NH&MRC

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    Keywords

    Wolbachia, siRNA, TOLL, Imd, JAK/STAT, RNAi, dengue virusHost-Parasite Interactions

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    CC BY 4.0

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