COMPLEXO: identifying the missing heritability of breast cancer via next generation collaboration

Coordinated international collaboration offers great potential to advance the discovery of additional breast cancer susceptibility genes. COMPLEXO was established to facilitate collaborations between researchers actively applying massively parallel sequencing to further understand the genetics of breast and ovarian cancer. COMPLEXO has 38 member Institutions (spanning 23 countries) and more than 1,000 combined human exomes from women at high risk of breast cancer. The consortium defined activities and brought together data and resources suitable for exome/genome sequencing initiatives and large case-control-family study resources suitable for validation of candidate susceptibility genes in which rare mutations are associated with high to moderate risk of breast cancer. Publication this data set supports:

COMPLEXO, Southey MC, Park DJ, Nguyen-Dumont T, Campbell I, Thompson E, Trainer AH, Chenevix-Trench G, Simard J, Dumont M, Soucy P, Thomassen M, Jønson L, Pedersen IS, Hansen TV, Nevanlinna H, Khan S, Sinilnikova O, Mazoyer S, Lesueur F, Damiola F, Schmutzler R, Meindl A, Hahnen E, Dufault MR, Chris Chan T, Kwong A, Barkardóttir R, Radice P, Peterlongo P, Devilee P, Hilbers F, Benitez J, Kvist A, Törngren T, Easton D, Hunter D, Lindstrom S, Kraft P, Zheng W, Gao YT, Long J, Ramus S, Feng BJ, Weitzel JN, Nathanson K, Offit K, Joseph V, Robson M, Schrader K, Wang S, Kim YC, Lynch H, Snyder C, Tavtigian S, Neuhausen S, Couch FJ, Goldgar DE. COMPLEXO: identifying the missing heritability of breast cancer via next generation collaboration. Breast Cancer Res. 2013 Jun 21;15(3):402. doi: 10.1186/bcr3434. PMID: 23809231; PMCID: PMC3706918.