Data on the wMel Wolbachia releases and monitoring in the cities of Bello, Medellin and Itagui in the Aburra Valley, Colombia, aggregated by release area and month. This data underlies the analyses and figures in the manuscript 'Large-scale releases and establishment of wMel Wolbachia in Aedes aegypti mosquitoes throughout the Cities of Bello, Medellín and Itagüí, Colombia' published in PLoS Neglected Tropical Diseases in 2023.