Structural studies of sensing domains of transducer-like proteins from Campylobacter jejuni and Helicobacter pylori

Chemotaxis is the directed movement in response to extracellular chemical gradients, which allows motile bacteria to find optimum environmental conditions for their proliferation. Environmental stimuli are detected by a set of membrane-associated chemoreceptors, which transmit the information to cytoplasmic components and modulate bacterial movement. In the present study, a comprehensive structural analysis of the sensory domains of chemoreceptors from two pathogens Campylobacter jejuni and Helicobacter pylori was carried out. The results of this investigation provide important insights of the molecular mechanisms by which chemoreceptors recognise diverse molecules.