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5313751_HumaZthesisFinal20170816.pdf (16.83 MB)

Structural and Functional Analysis of Chemokine Receptor CCR2 and its Cognate Chemokines

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thesis
posted on 2017-08-17, 04:21 authored by ZIL E HUMA
An important aspect of inflammation, the body’s response to injury or infection, is the migration of white blood cells into the affected tissues. White blood cell migration is controlled by proteins called chemokines, which are produced in the damaged tissues and interact with receptors on the surface of the blood cells. This project investigated molecular details of how a receptor can respond differently to distinct chemokine signals. The results of this study will help to guide future development of medicines to control white blood cell migration during inflammatory diseases like atherosclerosis, diabetes and obesity.

History

Principal supervisor

Martin Stone

Additional supervisor 1

Meritxell Canals

Year of Award

2017

Department, School or Centre

Biomedical Sciences (Monash Biomedicine Discovery Institute)

Additional Institution or Organisation

Biochemistry and Molecular Biology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

Doctorate

Faculty

Faculty of Medicine Nursing and Health Sciences

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    Faculty of Medicine, Nursing and Health Sciences Theses

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