File(s) under embargo

146

days

8

hours

until file(s) become available

Noscapine and its derivatives as microtubule-targeted cancer therapeutics

thesis
posted on 13.02.2020 by CASSANDRA SHU-XIN YONG
Noscapine, a phthalideisoquinoline alkaloid, is the second most abundant opium alkaloid derived from the opium poppy, Papaver somniferum. The anti-mitotic potential of noscapine was recently discovered, with no visible toxicity in the vital organs of tumour-implanted mice. Moreover, the low susceptibility of noscapine to the common multi-drug resistance (MDR) through increased efflux by drug transporters (ABCB1 and ABCG2) is of significant importance. Although noscapine possesses low cytotoxic activity, several semisynthetic noscapine derivatives have been reported to show a vast improvement in cytotoxic activity against various cancer cell lines, indicating the potential for noscapine to be developed for clinical use.

History

Campus location

Australia

Principal supervisor

Peter Scammells

Additional supervisor 1

Ben Capuano

Additional supervisor 2

Shane Devine

Year of Award

2020

Department, School or Centre

Medicinal Chemistry

Additional Institution or Organisation

Monash Institute of Pharmaceutical Sciences

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Exports