Non-canonical TGF-beta signaling drives neuronal guidance in C. elegans

Correct development of brain architecture depends on the proper coordination of conserved developmental signaling pathways. This thesis focuses on the role of highly conserved transforming growth factor beta signaling pathway in the control of neuronal development using the roundworm Caenorhabditis elegans as a model organism. The outcome of this study provides novel insight into how cell signaling events regulate the development of the nervous system and may have implications for human brain development.