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Reason: Under embargo until September 2020. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Investigation of the Mechanistic Roles of TLR2 and TLR9 in Gastric Cancer

thesis
posted on 2019-09-03, 05:12 authored by KE TANG
This thesis investigates the mechanistic roles of TLR2 and TLR9 in gastric cancer (GC) which is one of the deadliest cancers worldwide and lacks effective treatment currently. Both genes are upregulated and play tumor-promoting roles in GC, but in different stages and with different mechanisms (TLR2 has a more prominent role in driving the growth of established tumors, while TLR9 promotes the earlier inflammation-associated initiating stages of GC). The data of this thesis reveal the complexity of these innate immune sensors’ contribution to the tumorigenesis of human cancer, and highlight their potential to serve as new therapeutic targets of GC.

History

Principal supervisor

Brendan Jenkins

Additional supervisor 1

Daniel Croagh

Year of Award

2019

Department, School or Centre

Central Clinical School

Additional Institution or Organisation

Molecular and Translational Science (Hudson Institute)

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences

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    Faculty of Medicine, Nursing and Health Sciences Theses

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