MAjamian_Thesis_12.06.2019.pdf (8.96 MB)
Investigating Markers of Intestinal Barrier Dysfunction in Gastrointestinal Diseases
thesis
posted on 2019-06-14, 03:38 authored by MARY AIDA AJAMIANThis thesis studies circulating biomarkers of intestinal epithelial barrier integrity and function in human models. The results reveal that the protein zonulin, as it currently stands, is not a useful marker. However, a combination of other markers indicative of epithelial injury and and bacterial translocation provide insights into the heterogeneity of barrier dysfunction, localisation of intestinal injury, and modulation of the intestinal epithelium by diet and other factors.
History
Principal supervisor
Peter GibsonAdditional supervisor 1
Gennaro RosellaYear of Award
2019Department, School or Centre
Central Clinical SchoolCampus location
AustraliaCourse
Doctor of PhilosophyDegree Type
DOCTORATEFaculty
Faculty of Medicine Nursing and Health SciencesUsage metrics
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Keywords
MedicineGastroenterology and HepatologyImmunologyLeaky GutBiomarkersNon-Coeliac Wheat SensitivityCoeliac DiseaseUlcerative ColitisZonulinSyndecan-1I-FABPLBPsCD14FODMAPExercise-Induced Gastrointestinal SyndromeIntestinal permeabilityIntestinal barrierMicrobial transloactionBacterial translocationGastroenterology and HepatologyImmunologyMedicine
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