Monash University
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MAjamian_Thesis_12.06.2019.pdf (8.96 MB)

Investigating Markers of Intestinal Barrier Dysfunction in Gastrointestinal Diseases

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thesis
posted on 2019-06-14, 03:38 authored by MARY AIDA AJAMIAN
This thesis studies circulating biomarkers of intestinal epithelial barrier integrity and function in human models. The results reveal that the protein zonulin, as it currently stands, is not a useful marker. However, a combination of other markers indicative of epithelial injury and and bacterial translocation provide insights into the heterogeneity of barrier dysfunction, localisation of intestinal injury, and modulation of the intestinal epithelium by diet and other factors.

History

Principal supervisor

Peter Gibson

Additional supervisor 1

Gennaro Rosella

Year of Award

2019

Department, School or Centre

Central Clinical School

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences