Monash University
Browse
Matt_bentley_thesis_submission_FINAL.pdf (13.04 MB)

Development of the diaryl ether scaffold as inhibitors of EcDsbA using a fragment-based approach

Download (13.04 MB)
thesis
posted on 2020-05-11, 05:15 authored by MATTHEW ROSS BENTLEY
Antibiotic resistance is becoming a global health threat and drugs with novel mechanisms of action are required to provide new approaches to the treatment of bacterial infections and to combat resistance. This thesis examines the development of a series of novel anti-bacterial compounds targeting the bacterial enzyme DsbA. DsbA is required for the correct folding of many proteins that the bacteria use to establish an infection. Inhibitors of DsbA have the potential to “disarm” bacteria and thereby render them avirulent. As such DsbA inhibitors would represent a novel therapeutic approach to the treatment of bacterial infections.

History

Campus location

Australia

Principal supervisor

Martin J Scanlon

Additional supervisor 1

Ben Capuano

Year of Award

2020

Department, School or Centre

Medicinal Chemistry

Additional Institution or Organisation

Parkville

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Pharmacy and Pharmaceutical Sciences

Usage metrics

    Faculty of Pharmacy and Pharmaceutical Sciences Theses

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC