Biomimetic nanomaterials as nanomedicine against amyloid diseases

2020-01-05T09:26:18Z (GMT) by IBRAHIM JAVED
Amyloidosis are a group of diseases where a specific protein misfolds and aggregates into long twisted fibers called amyloids. Representative amyloid diseases include type 2 diabetes, Alzheimer’s and Parkinson’s disease. This phenomenon of protein fibrillization is also observed with the proteins of non-pathogenic origins such as whey proteins, i.e., β-lactoglobulin and caseins, where biocompatible amyloids are rendered under artificial conditions. This thesis investigates the innovative use of whey proteins to craft nanomedicines against amyloid diseases through tailored biophysical interactions. It also provides zebrafish as a high-throughput animal model for rapid screening of anti-amyloid medicines.