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An investigation into the function of KATNAL2 in male fertility and health

posted on 02.05.2018, 02:42 by JESSICA ELIZABETH MAREE DUNLEAVY
Male infertility affects one in twenty men of reproductive age in Australia. Despite this the underlying causes of many common defects remain poorly defined. This thesis predominantly explored the processes by which spermatogonial stem cells transform into aerodynamic, motile sperm capable of fertilising an egg. Using sophisticated experimental approaches, previously overlooked mechanisms were identified to be of critical relevance to male fertility and to cell biology more broadly. The discoveries made in this project will aid in understanding the causes of genetic based infertility, and, in addition, have provided insight into the pathophysiology of other diseases including hydrocephaly.


Principal supervisor

Moira Kathleen O'Bryan

Year of Award


Department, School or Centre

Anatomy and Developmental Biology

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences