Advancing the understanding of opioid receptor biology and function in the enteric nervous system

2019-06-11T06:33:50Z (GMT) by JESSE JAMES DI CELLO
Opioids have been used for centuries for their analgesic and antidiarrheal properties. However, their use can be severely limited by side-effects including constipation. This thesis examined novel concepts of how opioids regulate gut function. It identified potential approaches through which opioid therapeutics with reduced gastrointestinal side-effects may be developed.