Jesse Di Cello_Final Revised Thesis_2019.pdf (37.53 MB)
Advancing the understanding of opioid receptor biology and function in the enteric nervous system
thesis
posted on 2019-06-11, 06:33 authored by JESSE JAMES DI CELLOOpioids have been used for centuries for their analgesic and antidiarrheal properties. However, their use can be severely limited by side-effects including constipation. This thesis examined novel concepts of how opioids regulate gut function. It identified potential approaches through which opioid therapeutics with reduced gastrointestinal side-effects may be developed.