%0 Thesis %A GRYNBERG, KEREN %D 2019 %T The JNK signalling pathway in renal ischaemia reperfusion injury %U https://bridges.monash.edu/articles/thesis/The_JNK_signalling_pathway_in_renal_ischaemia_reperfusion_injury/9758345 %R 10.26180/5d6df64ba83d9 %K JNK %K Acute kidney injury %K Ischaemia reperfusion injury %K Medicine %X Acute kidney injury (AKI) is a serious condition which can be anticipated in situations like cardiac surgery. This thesis identifies the JNK1 enzyme as a key driver of cell death and inflammation in acute kidney injury. Pre-clinical studies showing protection with pharmacological JNK inhibition raise the potential for clinical trials. %I Monash University