The Interplay of Cytokines in the Pathogenesis of Female Reproductive Cancer IRENE PAPAGEORGIOU 10.26180/5d6df65a5526d https://bridges.monash.edu/articles/thesis/The_Interplay_of_Cytokines_in_the_Pathogenesis_of_Female_Reproductive_Cancer/9750962 This thesis sought to examine the interplay of key molecular processes involved in the pathogenesis of cancer. Ground-breaking re-emergence of Nodal/Cripto was detected in endometrial cancer patient samples compared to healthy controls. Interestingly blockade of Nodal/Cripto activities, using monoclonal antibody treatment significantly reversed the carcinogenic behaviour of cellular models. This thesis also examined another molecule, with important functions within the female reproductive tract, the Interferon Epsilon. It was demonstrated that Interferon Epsilon treatment of aggressive endometrial cancer cells dramatically reduced cell growth. These findings could be utilized in the potential development of novel therapeutic agents for endometrial cancer. 2019-09-03 05:12:45 Nodal Cripto Interferon Interferon Epsilon Reproduction Obstetrics and Gynaecology Cell Biology Molecular Biology