10.26180/5c6b4b6d5ec2b
ASHLEY RYAN MURPHY
ASHLEY RYAN
MURPHY
Three-Dimensional Human Neural Cell Culture Using Tailored Porous Polymer Scaffolds
Monash University
2019
3D scaffold
neural differentiation
tissue engineering
3D cell culture
neural stem cell
neuron
Regenerative Medicine (incl. Stem Cells and Tissue Engineering)
Biomaterials
2019-02-19 00:18:51
Thesis
https://bridges.monash.edu/articles/thesis/Three-Dimensional_Human_Neural_Cell_Culture_Using_Tailored_Porous_Polymer_Scaffolds/7733021
The culture of cells in flat, stiff, two-dimensional environments often results in cells dissimilar to those found in the human body. This can be detrimental in the translation of research outcomes from dish to human, and is particularly evident in the poor success of new neurological drugs. Conversely, neural cells cultured in three-dimensions, typically with the aid of a scaffold, have shown to be more comparable to those found in the brain. This thesis investigates the creation of a three-dimensional neurological drug screening device using a novel porous polymer cell culture scaffold paired with human neural stem cells.