10.26180/5c3ec4938becb FARRAH SHAFEERA IBRAHIM FARRAH SHAFEERA IBRAHIM IDENTIFICATION OF EARLY POTENTIAL BIOMARKER FOR EARLY DIABETIC NEPHROPATHY Monash University 2019 Diabetic nephropathy early biomarker proteomic 2 dimensional electrophoresis prediabetes Physiology 2019-01-16 05:43:45 Thesis https://bridges.monash.edu/articles/thesis/IDENTIFICATION_OF_EARLY_POTENTIAL_BIOMARKER_FOR_EARLY_DIABETIC_NEPHROPATHY/7592900 Diabetic Nephropathy (DN) is a major diabetic complication that leads to end-stage renal disease. This thesis examines early biomarkers for DN using the proteomic approach in normal, pre-diabetes, early-diabetes, and established-diabetes group. It identifies the early potential biomarker at the pre-diabetes stage which increases by 4.5-fold within the 12-month period, while the current marker (ACR) did not display any changes. Accordingly, it could be part of a biomarker panel aimed to identify people considered as high-risk of developing DN.