%0 Thesis %A BALIC, JESSE JAY %D 2018 %T Investigation of STAT3 Serine Phosphorylation in Gastric Tumourigenesis %U https://bridges.monash.edu/articles/thesis/Investigation_of_STAT3_Serine_Phosphorylation_in_Gastric_Tumourigenesis/7396937 %R 10.26180/5bff1dd9e92f0 %K JAK-STAT Signalling %K Gastric Cancer %K Gastritis %K Helicobacter infection %K Cancer Cell Biology %K Biochemistry %K Molecular Biology %X Stomach cancer is a common worldwide health burden. It is aggressive and often diagnosed at a late stage. Currently, no blood test can detect this cancer and no curative treatment options are available. This thesis examined the role of a cancer causing protein called STAT3. It was discovered that this protein requires a special modification for its capacity to promote stomach inflammation and tumour growth. This study importantly defines a brand new therapeutic opportunity for the development of drugs that can target this modification, in the hopes to finally finding a cure for this lethal disease. %I Monash University