10.26180/5ba8332aefb7e
XIN SUN
XIN
SUN
The Epigenetic Control of Mitochondrial DNA Copy Number in Tumorigenesis and Differentiation
Monash University
2018
mitochondrial DNA
Epigenetics
tumorigenesis
differentiation
Cancer Genetics
Epigenetics (incl. Genome Methylation and Epigenomics)
2018-09-24 00:43:21
Thesis
https://bridges.monash.edu/articles/thesis/The_Epigenetic_Control_of_Mitochondrial_DNA_Copy_Number_in_Tumorigenesis_and_Differentiation/7121753
This thesis focuses on how the communication between the two genomes within a cell, namely the nuclear and mitochondrial genomes, is disrupted in cancer. It identifies abnormal levels in modifications to both genomes, as determined by the levels of DNA methylation, which regulate the number of mitochondrial DNA copies in a cancer cell. It suggests that a cell needs to establish harmony between these two genomes and provides potential implications for cancer treatments.