10.4225/03/5b2f1cf518867 ALICE ESTHER BERIZZI ALICE ESTHER BERIZZI Modulation of Muscarinic Acetylcholine Receptors in Ethanol-seeking Behaviours Monash University 2018 muscarinic receptors allosteric modulation alcohol use disorders addiction Behavioral Neuroscience Pharmacology Neuroscience 2018-06-24 04:24:18 Thesis https://bridges.monash.edu/articles/thesis/Modulation_of_Muscarinic_Acetylcholine_Receptors_in_Ethanol-seeking_Behaviours/6664205 The M5 muscarinic receptor is a protein that can regulate the compulsive use of abused drugs, including cocaine and morphine, and therefore has emerged as an interesting drug target for the treatment of alcohol use disorders. Until recently, drugs that selectively target the M5 muscarinic receptor have been lacking. This thesis sought to identify and understand how selective drugs for the M5 muscarinic receptor act and their utility in models of alcohol use disorders.