10.4225/03/5b2f1cf518867
ALICE ESTHER BERIZZI
ALICE ESTHER
BERIZZI
Modulation of Muscarinic Acetylcholine Receptors in Ethanol-seeking Behaviours
Monash University
2018
muscarinic receptors
allosteric modulation
alcohol use disorders
addiction
Behavioral Neuroscience
Pharmacology
Neuroscience
2018-06-24 04:24:18
Thesis
https://bridges.monash.edu/articles/thesis/Modulation_of_Muscarinic_Acetylcholine_Receptors_in_Ethanol-seeking_Behaviours/6664205
The M5 muscarinic receptor is a protein that can regulate the compulsive use of abused drugs, including cocaine and morphine, and therefore has emerged as an interesting drug target for the treatment of alcohol use disorders. Until recently, drugs that selectively target the M5 muscarinic receptor have been lacking. This thesis sought to identify and understand how selective drugs for the M5 muscarinic receptor act and their utility in models of alcohol use disorders.