10.4225/03/5b10b9cb0a180 FITYA SYARIFA MOZAR FITYA SYARIFA MOZAR Delivery of Anti Cancer Drugs to Breast Cancer Cells using pH-sensitive Inorganic Nanoparticles Monash University 2018 breast cancer nanoparticle nanomedicine carbonate apatite Cancer Nanomedicine 2018-06-01 03:13:13 Thesis https://bridges.monash.edu/articles/thesis/Delivery_of_Anti_Cancer_Drugs_to_Breast_Cancer_Cells_using_pH-sensitive_Inorganic_Nanoparticles/6400061 pH-sensitive inorganic nanoparticles have shown enormous potential as chemotherapeutic drug delivery carriers. Three different nanocrystals namely carbonate apatite (CA), strontium sulfite (SrSO3), and strontium fluoride (SrF2) were fabricated in this study and subsequently delivered to breast cancer cells after incorporation with selected anticancer drugs. These treatment effectivities were assessed both in vitro using human and mice breast cancer cell lines, as well as in vivo using tumor-bearing mice models. Biodegradability, versatility, cost-effective and easy fabrication technique gives these nanocrystals marked advantages compared to other conventional nanoparticles.