10.4225/03/5b10b9cb0a180
FITYA SYARIFA MOZAR
FITYA SYARIFA
MOZAR
Delivery of Anti Cancer Drugs to Breast Cancer Cells using pH-sensitive Inorganic Nanoparticles
Monash University
2018
breast cancer
nanoparticle
nanomedicine
carbonate apatite
Cancer
Nanomedicine
2018-06-01 03:13:13
Thesis
https://bridges.monash.edu/articles/thesis/Delivery_of_Anti_Cancer_Drugs_to_Breast_Cancer_Cells_using_pH-sensitive_Inorganic_Nanoparticles/6400061
pH-sensitive inorganic nanoparticles have shown enormous potential as chemotherapeutic drug delivery carriers. Three different nanocrystals namely carbonate apatite (CA), strontium sulfite (SrSO3), and strontium fluoride (SrF2) were fabricated in this study and subsequently delivered to breast cancer cells after incorporation with selected anticancer drugs. These treatment effectivities were assessed both in vitro using human and mice breast cancer cell lines, as well as in vivo using tumor-bearing mice models. Biodegradability, versatility, cost-effective and easy fabrication technique gives these nanocrystals marked advantages compared to other conventional nanoparticles.