Tackling Polymyxin Resistance in Pseudomonas aeruginosa: A Multi-disciplinary Approach MEILING HAN 10.4225/03/5ab8414c4fba8 https://bridges.monash.edu/articles/thesis/Tackling_Polymyxin_Resistance_in_Pseudomonas_aeruginosa_A_Multi-disciplinary_Approach/6010841 This thesis, for the first time, provides an important mechanistic insight into the comprehensive mechanisms of polymyxin resistance in P. aeruginosa through the integrated neutron reflectometry and systems pharmacological approaches. Our research highlighted the complex and dynamic interactions of multiple cellular metabolic pathways involved in the bacterial physiological response to polymyxins, and their potential as therapeutic targets. Our study has made a significant contribution to understanding polymyxin mode of action and helps to tackle polymyxin resistance in Gram-negative "superbugs". 2018-03-26 00:39:37 Antimicrobial resistance Gram-negative bacteria Metabolomics Neutron reflectometry Polymyxin Pseudomonas aeruginosa Systems pharmacology Pharmaceutical Sciences Pharmacology