Tackling Polymyxin Resistance in Pseudomonas aeruginosa: A Multi-disciplinary Approach
MEILING HAN
10.4225/03/5ab8414c4fba8
https://bridges.monash.edu/articles/thesis/Tackling_Polymyxin_Resistance_in_Pseudomonas_aeruginosa_A_Multi-disciplinary_Approach/6010841
This thesis, for the first time, provides an important mechanistic insight into the comprehensive mechanisms of polymyxin resistance in P. aeruginosa through the integrated neutron reflectometry and systems pharmacological approaches. Our research highlighted the complex and dynamic interactions of multiple cellular metabolic pathways involved in the bacterial physiological response to polymyxins, and their potential as therapeutic targets. Our study has made a significant contribution to understanding polymyxin mode of action and helps to tackle polymyxin resistance in Gram-negative "superbugs".
2018-03-26 00:39:37
Antimicrobial resistance
Gram-negative bacteria
Metabolomics
Neutron reflectometry
Polymyxin
Pseudomonas aeruginosa
Systems pharmacology
Pharmaceutical Sciences
Pharmacology