10.4225/03/5aaf3a2a9d5ba
MICHELLE WENDY PEARCE
MICHELLE WENDY
PEARCE
Investigating the function of phospholipid flippases in Drosophila melanogaster
Monash University
2018
Olfaction
Phospholipid flippase
Cell membrane
Cell Biology
Genetics
Molecular Biology
2018-03-19 04:18:49
Thesis
https://bridges.monash.edu/articles/thesis/Investigating_the_function_of_phospholipid_flippases_in_Drosophila_melanogaster/5986729
Drosophila have three receptor families that detect odours in their environment. In order to function properly one of these families, the odorant receptor family, requires the phospholipid flippase protein, dATP8B. Phospholipid flippases maintain the composition of important lipids in cellular membranes. My research showed that that when the dATP8B protein is non-functional, the amount of odorant receptor in olfactory cell membranes is substantially reduced, causing an olfactory defect. The functions of the other five Drosophila flippases were also explored and putative roles for three of these were found.