New materials for cancer imaging and therapy ROBBIN RALF VERNOOIJ 10.4225/03/5aa7347024809 https://bridges.monash.edu/articles/thesis/New_materials_for_cancer_imaging_and_therapy/5951023 The increasing burden of cancer on society drives the development of more effective chemotherapeutic agents. The work in this thesis is therefore centred on the examination of a new series of metal-based anticancer prodrug candidates. These metal-based compounds do not exhibit toxicity in the dark, but can be activated with light in cancerous areas, avoiding unwanted side-effects in healthy tissues. A range of state-of-the- art spectroscopic techniques, including vibrational spectroscopy and synchrotron radiation, are applied to study the chemical and biological properties of these compounds, revealing new insights into their mechanism of action. 2018-03-12 23:10:35 anticancer agents vibrational spectroscopy mechanism of action Inorganic Chemistry Physical Chemistry of Materials Computational Chemistry