Multivalent Ligands as Chemical Probes for the Investigation of Dopamine D2 Receptor Pharmacology
ANITHA KOPINATHAN
10.4225/03/59b5ce6a65d01
https://bridges.monash.edu/articles/thesis/Multivalent_Ligands_as_Chemical_Probes_for_the_Investigation_of_Dopamine_D2_Receptor_Pharmacology/5383117
The dopamine D<sub>2</sub> receptor is a well-established therapeutic target for the treatment of central nervous system disorders such as schizophrenia and Parkinson’s disease. Although a number of treatments have been developed to target this receptor, our understanding of the structural and pharmacological aspects of the dopamine D<sub>2</sub> receptor are still in its infancy. This thesis describes the design, synthesis and biological evaluation of chemical probes to investigate the structure and pharmacology of the dopamine D<sub>2</sub> receptor. Through this work, it is envisaged that these probes will aid the development of novel treatments for central nervous system disorders with reduced side-effects.
2017-09-10 23:44:40
Dopamine
D2 receptor
multivalent ligands
chemical probes
receptor pharmacology
Medicinal and Biomolecular Chemistry not elsewhere classified