Adenosine A2B Receptor Pharmacology and its Role in Pathophysiology ELIZABETH ANN VECCHIO 10.4225/03/599238598ac80 https://bridges.monash.edu/articles/thesis/Adenosine_A2B_Receptor_Pharmacology_and_its_Role_in_Pathophysiology/5306617 The adenosine A<sub>2B</sub> receptor is an important but poorly understood drug target. This thesis investigated new paradigms of adenosine A<sub>2B</sub> receptor signalling and behaviour and identified drugs that could selectively promote beneficial outcomes in prostate cancer cells and cardiac fibroblasts. This information helps to inform how targeting the adenosine A<sub>2B</sub> receptor may be used as a treatment for prostate cancer and cardiovascular disease. 2017-08-14 23:55:03 Adenosine A2B receptor Prostate cancer Fibrosis Pharmacology