Adenosine A2B Receptor Pharmacology and its Role in Pathophysiology
ELIZABETH ANN VECCHIO
10.4225/03/599238598ac80
https://bridges.monash.edu/articles/thesis/Adenosine_A2B_Receptor_Pharmacology_and_its_Role_in_Pathophysiology/5306617
The adenosine A<sub>2B</sub> receptor is an important but poorly understood drug target. This thesis investigated new paradigms of adenosine A<sub>2B</sub> receptor signalling and behaviour and identified drugs that could selectively promote beneficial outcomes in prostate cancer cells and cardiac fibroblasts. This information helps to inform how targeting the adenosine A<sub>2B</sub> receptor may be used as a treatment for prostate cancer and cardiovascular disease.
2017-08-14 23:55:03
Adenosine A2B receptor
Prostate cancer
Fibrosis
Pharmacology