Dynamic X-ray imaging of mice in vivo to investigate lung function and structure in ventilator-induced lung injury MELISSA HELENE PREISSNER 10.26180/5ec79e0724b97 https://bridges.monash.edu/articles/thesis/Dynamic_X-ray_imaging_of_mice_in_vivo_to_investigate_lung_function_and_structure_in_ventilator-induced_lung_injury/12356606 When the lungs begin to fail, mechanical ventilation is a life-saving intervention. However, mechanical ventilation can also damage the delicate structures in the lung, known as ventilator-induced lung injury. The risk increases substantially when the lungs are in a pathological state, such as with acute respiratory distress syndrome, where hospital mortality remains unacceptably high. In this PhD thesis, a recent development in laboratory-based, dynamic X-ray CT imaging, combined with customised image analysis, is used to investigate changes to the delicate structures in the mechanically-ventilated mouse lung, in order to better understand ventilator-induced lung injury. 2020-05-22 09:40:21 dynamic x-ray imaging VILI ARDS Biological Engineering