10.26180/5e3a1760052bb
MONICA PAUL GONEY
MONICA PAUL
GONEY
PHYSIOLOGY AND THERAPEUTIC POTENTIAL OF INHIBIN
Monash University
2020
Inhibin
Physiology
2020-02-05 01:16:14
Thesis
https://bridges.monash.edu/articles/thesis/PHYSIOLOGY_AND_THERAPEUTIC_POTENTIAL_OF_INHIBIN/11803746
Post-menopausal women experience adverse changes to the musculoskeletal, metabolic and reproductive systems, resulting from the loss of ovarian hormones (inhibin and oestrogen). Whilst the consequence of oestrogen loss is well-defined, the exact consequence of inhibin loss is unknown. This thesis developed a mouse model of inhibin deficiency, and found inhibin loss promotes obesity - analogous to weight gain in postmenopausal women. This indicates inhibin is a preserver of metabolic health, which may be used to alleviate postmenopausal complications. Accordingly, this thesis generated clinical grade inhibin, with enhanced potency (up to 20-fold), for therapeutic assessment. These tools will determine the physiological and therapeutic potential of inhibin, in a menopause setting.