10.26180/5e3a1760052bb MONICA PAUL GONEY MONICA PAUL GONEY PHYSIOLOGY AND THERAPEUTIC POTENTIAL OF INHIBIN Monash University 2020 Inhibin Physiology 2020-02-05 01:16:14 Thesis https://bridges.monash.edu/articles/thesis/PHYSIOLOGY_AND_THERAPEUTIC_POTENTIAL_OF_INHIBIN/11803746 Post-menopausal women experience adverse changes to the musculoskeletal, metabolic and reproductive systems, resulting from the loss of ovarian hormones (inhibin and oestrogen). Whilst the consequence of oestrogen loss is well-defined, the exact consequence of inhibin loss is unknown. This thesis developed a mouse model of inhibin deficiency, and found inhibin loss promotes obesity - analogous to weight gain in postmenopausal women. This indicates inhibin is a preserver of metabolic health, which may be used to alleviate postmenopausal complications. Accordingly, this thesis generated clinical grade inhibin, with enhanced potency (up to 20-fold), for therapeutic assessment. These tools will determine the physiological and therapeutic potential of inhibin, in a menopause setting.