Cyclodextrin mediated protection after diffuse traumatic brain injury KATHERINE LOUISE GILLESPIE-JONES 10.26180/5dccc510364cb https://bridges.monash.edu/articles/thesis/Cyclodextrin_mediated_protection_after_diffuse_traumatic_brain_injury/10302197 Traumatic brain injury (TBI) is a major public health issue worldwide with those surviving the initial head injury experiencing long-lasting debilitating consequences. These injuries are commonly caused by car accidents, sporting field blows and falls in the general population; and exposure to explosive devices in military personnel. There is still no drug intervention available that reduces the long-term symptoms experienced by patients. In this thesis, we have shown for the first time in TBI, that a novel drug candidate cyclodextrin can markedly reduce brain dysfunction after injury, potentially through the modulation of cholesterol and maintenance of cerebral blood vessels. 2019-11-14 03:07:58 Traumatic Brain Injury Physiology Neuroscience